The science behind Jude Supplements


List of research papers: Effects of pumpkin seed on incontinence/ BPH/ prostate cancer/ kidney stone papers
https://www.maturitas.org/article/S0378-5122(19)30651-6/fulltext

https://www.ncbi.nlm.nih.gov/p

<h4 dir="ltr" id="isPasted" style="line-height: 1.5;">There are many research papers recognised by the European Food Safety Authority (EFSA) establishing the efficacy of Jude&apos;s key ingredients in our Bladder Strength Supplements.&#xA0;</h4>Below are two key studies we referenced when creating our product:<h4 dir="ltr" style="line-height: 2;" id="study-one-effect-of-supplementation-with-high-genistein-soybean-isoflavones-and-pumpkin-standardized-extract-on-urinary-incontinence">Study One: Effect of Supplementation with High Genistein Soybean Isoflavones and Pumpkin Standardized Extract on Urinary Incontinence</h4>Study Highlights: This study demonstrated that supplementation with a combination of high genistein soybean isoflavones and standardised pumpkin extract significantly alleviates urinary incontinence symptoms in perimenopausal women. The treatment not only reduced the frequency of urgency and nocturia but also markedly improved the overall quality of life for participants.Study Design and Protocol: The study was an open prospective trial involving 82 healthy perimenopausal women diagnosed with urinary incontinence. The primary objective was to evaluate the effectiveness of a dietary supplement comprising high genistein soybean extract and pumpkin seed extract.Participants were instructed to take two tablets per day for the first four weeks, followed by one tablet per day for the next four weeks. The study spanned a total of eight weeks, with measurements taken before the start of the treatment, during the treatment, and at the end of the protocol.Analysis and Summary:<ul><li style="font-family: Arial, Helvetica, sans-serif;">Urgency Grade:&#xA0;Reduced by 24.7% (P&lt;0.01)</li><li style="font-family: Arial, Helvetica, sans-serif;">Nocturia:&#xA0;Reduced by 69.35% (P&lt;0.05)</li><li style="font-family: Arial, Helvetica, sans-serif;">Daily Pantyliner Use:&#xA0;Reduced by 66.25% (P&lt;0.01)</li><li style="font-family: Arial, Helvetica, sans-serif;">Quality of Life:&#xA0;Improved in 92.3% of participants</li></ul>The findings confirm that the combination of pumpkin seed and soy germ extract is both safe and effective in reducing urinary incontinence symptoms while significantly enhancing the quality of life in perimenopausal women.<a href="https://www.researchgate.net/publication/321029023_Clinical_Study_Effect_of_Supplementation_with_High_Genistein_Soybean_Isoflavones_and_Pumpkin_Standardized_Extract_on_Urinary_Incontinence_in_Western_Perimenopausal_Women">Read the study here.</a><hr><h4 dir="ltr" style="line-height: 2;" id="study-two-a-randomized-double-blind-placebo-controlled-clinical-trial-of-a-product-containing-pumpkin-seed-extract-and-soy-germ-extract-to-improve-overactive-bladder-related-voiding-dysfunction-and-quality-of-life">Study Two: A Randomized Double-Blind Placebo-Controlled Clinical Trial of a Product Containing Pumpkin Seed Extract and Soy Germ Extract to Improve Overactive Bladder-Related Voiding Dysfunction and Quality of Life</h4>Study Highlights: This study investigated the efficacy of a novel combination of pumpkin seed extract and soy germ extract in treating overactive bladder (OAB) symptoms. The study&apos;s results indicated a significant reduction in OAB-related symptoms, including urgency and nighttime awakenings, with a concurrent improvement in quality of life among participants.Study Design and Protocol: This double-blind, placebo-controlled trial included 135 participants with diagnosed OAB. The subjects were randomized into two groups: one receiving the active supplement containing pumpkin seed and soy germ extract, and the other receiving a placebo.Participants were instructed to take two tablets per day for 12 weeks. Measurements of OAB symptoms, including voiding frequency, urgency, nocturia, and overall quality of life, were recorded at baseline, at 6 weeks, and at the end of the study.Analysis and Summary:<ul><li style="font-family: Arial, Helvetica, sans-serif;">Voiding Frequency:&#xA0;Reduced by 21.5% in the treatment group compared to 5.2% in the placebo group (P&lt;0.01)</li><li style="font-family: Arial, Helvetica, sans-serif;">Urgency Episodes:&#xA0;Decreased by 27.3% in the treatment group compared to 9.4% in the placebo group (P&lt;0.05)</li><li style="font-family: Arial, Helvetica, sans-serif;">Nocturia Episodes:&#xA0;Reduced by 35.7% in the treatment group (P&lt;0.01)</li><li style="font-family: Arial, Helvetica, sans-serif;">Quality of Life:&#xA0;Improved significantly in 87% of the treatment group participants (P&lt;0.01)</li></ul>The study concludes that the product containing pumpkin seed extract and soy germ extract is a beneficial and well-tolerated option for improving voiding dysfunction and enhancing the quality of life in individuals with overactive bladder.<a href="https://www.sciencedirect.com/science/article/abs/pii/S1756464614000826">Read the study here.</a><hr><h4 dir="ltr" style="line-height: 2;" id="there-is-also-a-plethora-of-other-studies-which-contain-our-key-nutrients-pumpkin-seed-andor-soygerm-extract-and-you-can-take-a-look-at-some-of-our-favourites-below">There is also a plethora of other studies which contain our key nutrients (pumpkin seed and/or soygerm extract) and you can take a look at some of our favourites below:</h4><ol><li style="font-family: Arial, Helvetica, sans-serif;"><a href="https://www.maturitas.org/article/S0378-5122(19)30651-6/abstract" style="text-decoration:none;">Evaluation of Femaxeen&#xAE; for control of urinary incontinence in women: A randomized, double-blind, placebo-controlled study</a></li><li style="font-family: Arial, Helvetica, sans-serif;"><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435946/" style="text-decoration:none;">Clinical study of effectiveness and safety of CELcomplex&#xAE; containing Cucurbita Pepo Seed extract and Flax and Casuarina on stress urinary incontinence in women</a></li><li style="font-family: Arial, Helvetica, sans-serif;"><a href="https://www.researchgate.net/publication/332650671_Effects_of_an_Oil-Free_Hydroethanolic_Pumpkin_Seed_Extract_on_Symptom_Frequency_and_Severity_in_Men_with_Benign_Prostatic_Hyperplasia_A_Pilot_Study_in_Humans" style="text-decoration:none;">Effects of an Oil-Free Hydroethanolic Pumpkin Seed Extract on Symptom Frequency and Severity in Men with Benign Prostatic Hyperplasia: A Pilot Study in Humans</a></li><li style="font-family: Arial, Helvetica, sans-serif;"><a href="https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-0946-2280" style="text-decoration:none;">Cucurbita pepo&#x2013;Rhus aromatica&#x2013;Humulus lupulus Combination Reduces Overactive Bladder Symptoms in Women &#x2013; A Noninterventional Study</a></li><li style="font-family: Arial, Helvetica, sans-serif;"><a href="https://karger.com/uin/article/94/3/286/322765/Effects-of-Pumpkin-Seed-in-Men-with-Lower-Urinary" style="text-decoration:none;">Effects of Pumpkin Seed in Men with Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia in the One-Year, Randomized, Placebo-Controlled GRANU Study</a></li><li style="font-family: Arial, Helvetica, sans-serif;"><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083134/" style="text-decoration:none;">Prospective Multicenter Open-Label One-Arm Trial Investigating a Pumpkin Seed, Isoflavonoids, and Cranberry Mix in Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: A Pilot Study</a></li><li style="font-family: Arial, Helvetica, sans-serif;"><a href="https://www.pagepressjournals.org/index.php/aiua/article/view/aiua.2016.2.136/5810" style="text-decoration:none;">The role of Cucurbita pepo in the management of patients affected by lower urinary tract symptoms due to benign prostatic hyperplasia.</a></li></ol><hr><h4 dir="ltr" style="line-height: 2;" id="finally-if-you-fancy-diving-further-into-the-science-there-are-more-than-25-research-papers-establishing-the-efficacy-of-soy-phytoestrogen-on-lower-urinary-tract-symptoms-luts-grab-a-cuppa-and-take-a-look-below">Finally, if you fancy diving further into the science, there are more than 25 research papers establishing the efficacy of Soy Phytoestrogen on Lower Urinary Tract symptoms (LUTs). Grab a cuppa and take a look below:</h4><ul><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Potent inhibition of human prostate cancer cells by genistein in vitro and in vivo depends on the oncogenic activity of the Erk pathway.<a href="https://pubmed.ncbi.nlm.nih.gov/14669453/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Adverse effects of phytoestrogens on reproductive health: a report of three cases.<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004126/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Inhibition of prostate cancer growth by genistein in vivo: Role of mitochondrial-mediated apoptosis and reduced nuclear factor-kappaB expression.<a href="https://pubmed.ncbi.nlm.nih.gov/10656454/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Plant-derived dietary polyphenolic compounds in prostate cancer chemoprevention.<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920717/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Association between urinary phytoestrogens and cognitive decline in older adults.<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504965/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Effects of isoflavone supplements on prostate-specific antigen: A meta-analysis of randomized controlled trials.<a href="https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(15)00705-0" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Effects of isoflavone supplements on prostate-specific antigen: A meta-analysis of randomized controlled trials.<a href="https://www.goldjournal.net/article/S0090-4295(15)00705-0/fulltext" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Influence of soy isoflavones on endometrial thickness in postmenopausal women: A randomized, double-blind, placebo-controlled trial.<a href="https://www.sciencedirect.com/science/article/abs/pii/S0531556509002356?via%3Dihub" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Isoflavone consumption and risk of recurrence in patients with breast cancer: The Life After Cancer Epidemiology study.<a href="https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(05)00259-8" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Soy isoflavones and breast cancer risk in postmenopausal women.<a href="https://pubmed.ncbi.nlm.nih.gov/17463164/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Phytoestrogens and prostate cancer: Possible preventive role.<a href="https://pubmed.ncbi.nlm.nih.gov/18804802/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Soy isoflavones and breast cancer risk in postmenopausal women.<a href="https://pubmed.ncbi.nlm.nih.gov/17463164/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Impact of phytoestrogen on prostate cancer cells: Growth inhibition and DNA damage.<a href="https://link.springer.com/article/10.1007%2Fs00210-011-0722-y" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Mechanisms of isoflavone-induced breast cancer cell apoptosis: Involvement of caspase-8 and cFLIP.<a href="https://www.sciencedirect.com/science/article/abs/pii/S0024320511002682?via%3Dihub" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Isoflavones as a potential chemopreventive agent for prostate cancer.<a href="https://pubmed.ncbi.nlm.nih.gov/23793100/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Impact of dietary isoflavones on prostate cancer progression in patients treated with brachytherapy.<a href="https://cebp.aacrjournals.org/content/27/11/1371.long" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Isoflavones and their impact on prostate cancer risk.<a href="https://www.sciencedirect.com/science/article/abs/pii/S1043661812001259?via%3Dihub" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Impact of soy consumption on prostate cancer prevention and treatment.<a href="https://www.auajournals.org/doi/10.1016/j.juro.2008.07.021" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Isoflavones and cognitive function in older adults.<a href="https://pubmed.ncbi.nlm.nih.gov/19462485/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Dietary isoflavones and cardiovascular health.<a href="https://pubmed.ncbi.nlm.nih.gov/32693763/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Soy isoflavones and prostate cancer: An updated review.<a href="https://pubmed.ncbi.nlm.nih.gov/27956174/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Effects of dietary isoflavones on blood pressure: A meta-analysis of randomized controlled trials.<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683370/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Dietary phytoestrogens and hormone replacement therapy: Effects on cognitive function.<a href="https://pubmed.ncbi.nlm.nih.gov/22268969/" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Isoflavones in the treatment of prostate cancer: Evidence from clinical trials.<a href="https://link.springer.com/article/10.1007%2Fs00210-013-0892-x" style="text-decoration:none;">&#xA0;Study here</a></li><li dir="ltr" style="font-family: Arial, Helvetica, sans-serif;">Association between isoflavone and lower urinary tract symptoms in elderly men.<a href="https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/association-between-isoflavone-and-lower-urinary-tract-symptoms-in-elderly-men/E9E124FA05C259D0382B6FB52685903D" style="text-decoration:none;">&#xA0;Study here</a></li></ul>

Where can I read the research on the Bladder Strength Supplement?

We carry out three rounds of third-party testing for all our products. The formulation for our supplement has been clinically proven in three trials. Whilst our pads and liners have been third party tested in a laboratory to see how they compare agai

We carry out three rounds of third-party testing for all our products. The formulation for our supplement has been clinically proven in three trials. Whilst our pads and liners have been third party tested in a laboratory to see how they compare against other incontinence brands.

How are Jude’s bladder care products clinically tested?

Our medical board consists of a range of leading doctors and urologists: 


Andrew Vallence Owen MBE:  Trained as a medical doctor and surgeon before going on to be Group Medical Director of Bupa. Currently Chief Medical Officer of the Medicover Grou

The Jude Medical Board consists of a range of leading doctors and urologists: <ul><li>Andrew Vallance-Owen MBE: Trained as a medical doctor and surgeon before going on to be Group Medical Director of Bupa. Currently Chief Medical Officer of the Medicover Group and chairman of the Private Healthcare Information Network.</li><li>Dr Shahzadi Harper: A dynamic doctor with a special interest in proactively optimising women&#x2019;s health and wellbeing. Expert in perimenopause, menopause and healthy ageing. Founder of the Harper Clinic.</li><li>Professor Leena Pradhan-Nabzdyk: Assistant Professor of Surgery at Harvard Medical with extensive experience in cardiovascular health, diabetes and allied areas. Expert in functional foods and is currently the CEO of Canomiks. Offers evidence-based insights into all things supplement related.</li><li>Jai Seth: Consultant urological surgeon who specialises in managing urinary continence issues. Co-leads the urodynamic, female urology and neuro-urology service at St George&apos;s Hospital and provides support for the bladder management of patients at the Royal Hospital for Neuro-disability.</li><li>Dr Masarat Jilani: Jude&apos;s resident doctor. A GP registrar who has worked in genito-urinary medicine.</li></ul>

Medical Board & Clinical Trials

Where can I read the research on the Bladder Strength Supplement?

How are Jude’s bladder care products clinically tested?

Who is on the Jude medical board?